Tricalcium phosphate is generally recognized as safe (GRAS) when used in accordance with good manufacturing practices.It is approved for use as a food additive by regulatory agencies such as the U.S. Food and Drug Administration (FDA), the European Food Safety Authority (EFSA), and other relevant authorities worldwide.

However, like any substance, there can be some safety concerns depending on the context of use.  The safety of tricalcium phosphate depends on its purity.Impurities or contaminants in the manufacturing process could potentially pose risks.It is crucial to ensure that the tricalcium phosphate used in food, pharmaceuticals, or other applications meets quality standards and specifications.

In the context of dietary supplements or fortified foods, excessive intake of calcium, including that from tricalcium phosphate, may lead to health issues.It is essential to follow recommended dosage guidelines and not exceed tolerable upper intake levels for calcium.

Some individuals may be allergic to certain sources of tricalcium phosphate, especially if it is derived from animal bones.People with specific allergies or dietary restrictions should be aware of the source of tricalcium phosphate used in products.

Excessive calcium intake, including from tricalcium phosphate supplements, can be a concern for individuals with kidney problems.Such individuals may have difficulty excreting excess calcium, potentially leading to hypercalcemia (elevated levels of calcium in the blood).

Calcium supplements, including tricalcium phosphate, can interact with certain medications.For example, calcium can interfere with the absorption of some antibiotics and thyroid medications.  Individuals taking medications should consult their healthcare provider before using calcium supplements.

As with any food additive or dietary supplement, it is advisable to use tricalcium phosphate responsibly and in accordance with recommended guidelines.If you have specific health concerns or conditions, it is recommended to consult with a healthcare professional before incorporating tricalcium phosphate into your diet or taking it as a supplement.